You can be pretty technical/capable and still write that article (especially if you have technical expertise outside programming). I have never felt so seen.

I worked my way up from arduino -> RasPi -> Debian -> Self hosting quite a few things. I’m very much a hobbyist/novice, but I’m used to learning. It is so hard to read some documentation and understand what something even does sometimes. This goes double for incredibly useful tools for monitoring/implementing other tools. Like I swear I read the kubernetes descriptions 30x before I realized what in the hell it actually does, and now I’m probably about to break my entire home network with it because I think it’s cool as hell.

Also, to your comment specifically: I can get sensors on PCBs I personally made collecting data, throwing it through my own MQTT broker, hosting a dashboard etc, all at a remote site across state lines. I have no idea wtf markdown is. I use yaml for HA stuff with the ESPs, but I don’t know why markdown is a thing and it’s not just python.

And I am 1000% sure there is a very good reason for 98% of this. But yes I found this article hilarious. In my personal circle of hell all nouns end in “-ly”.

I cannot emphasize enough how unwilling I’d be to interact with someone that has these.

Surely there’s enough for a macro pad in there? It’s like the makers version of a scratch off lotto ticket lmfao

2nd gramps. I spooled it up in about 2mins on an unraid server.

Ah, I thought the date was announced like two weeks ago. My mistake.

But in any event hope you get some good time in with it this weekend. When the vibe is that unique there’s nothing like a second helping done right.

Yeah, this was one of those games that I could see the craftsmanship but just wasn’t for me.

But strong follow up to a much beloved original IP for a very reasonable price? That borderline shadow dropped? Love it, yall enjoy your suprise Christmas and go nuts. Cool as hell.

I love this. I have a box I’ve been wanting to move to a family members place because they have fiber and I don’t. They’re heavy users of the plex server I have on there, so they’re happy to host it, but if I ever had issues around anything boot related I’d be down until I could physically get there.

This would also be awesome for troubleshooting some RasPi stuff where I kind of want the DE every now and then but mostly let it run headless.

I imagine it’s classified, but NASA being NASA, you know a full risk assessment along these lines exists, probably with dutiful updates as it’s still an active program. It would be fascinating read especially with the updates, with how much the world has changed while the probe remained the same.

I don’t get the panic. It worked great for 50% of Venture brothers.

I just want that snake. Is that some iconography I’ve missed? I have the rainbow gadsen on my range bag I want that one as well.

Not going to lie, despite loving the stories about the monkey king, I skipped it entirely because of the notes they sent to content creators. Which would also be why I skip movies and games that take the US’ DoD money. I’m glad it got passed over.

ooooh this is it! If you wanted to optimize evil add photosynthesis and nitrogen fixing and you’ve got it.

Hell, I’d bet you could work on the chloroplasts in isolation of the rest of the organism to parallel path the research and optimize.

I’ve been out of synthetic bio for damn near two decades now, and an undergrad when was I even in it, but I’m not so sure. PCR didn’t come around until 85. I had professors that used to do every cycle manually. Human genome project wrapped in 03(?). You can order custom oligos for like $0.13USD a base pair mail order now. You type it in on a webform, a machine creates a custom molecule for you, and if you want to pay a little extra you can have it over-night. I suppose it depends what you call “near future”, and synthetic biology has always had moving goal posts when it came to “functional liposome” and “synthetic life”, but I don’t know… shit can move fast sometimes.

you bet! I just remember that because we were learning about glucose is taken up (it’s an active process swapping sodium and potassium). Another fun bonus for you: thats what they figured out at university of florida (or at least implemented). Someone had the bright idea that if you gave athletes a beverage with not only glucose but the specific K+/Na+ they needed to run the enzymes that took up the glucose, they might perform better.

So the football team, the Gators, got a special concoction of “Gator-aide” at their games. It smelled kinda like sweat, wasn’t sweet (glucose isn’t actually that sweet), so the formula was eventually tweaked, the branding changed to “gatorade”, but the university still RAKES in the money for that license.

edit: Just to add another cool layer. The money to date has nothing to do with the innovation, that patent would have expired (which is fantastic because that concoction is basically how you treat all sorts of things like cholera where the body dies of dehydration despite having clean water, the UN, FEMA, etc basically hands out off-brand gatorade mix). The reason U of florida still gets the money isn’t formula, it’s the brand. Pepsi pays them for that “gator-aide” name. It’s rare IP perfect win; hydration mix for all, and if you there’s a business to be made selling it under a specific name so be it, doesn’t matter much to the person whos life is saved because of “generic hydration mix”.

Ok. THANK YOU. I also have to say my biggest issue with the newer one (I forget which) is when the parks going to hell, and the park director just decides to go off into the jungle. Like outside of just design of the park, there is NO way you don’t have rigid protocols in-place. Like you read about half the crap Disney does/can do at their parks… there’s no way the head of the park just goes “oh you guys got this, I’ll be back at some point, just do your best”.

Like if ONLY for the reason it would be a known PR disaster for something that in universe already had PR disasters… that shit would have been drilled in since day -1000. It’s my biggest issue with the writing because it’s not even sci-fi.

/end rant.

Sorry about your grandfather. There’s probably more than one mechanism for alzeimers (not an expert), but amaloyid plaque formation, which is definitely A way to develop alzheimer’s, is indeed a prion like event. I’m not sure if “prion” has some hyper-precise definition but the ideas similar: you get one amalyoid protein that misfolds, and acts as a nucleation site misfolding and agglomerating others.

“mirror sugar”. Just dropping some trivia. The first “no calorie” sweetners were actually mirror sugar. They’d activate tastebuds but couldn’t be adsorbed in the gut. Only problem was people crapped their brains out because the osmotic balance went to hell.

edit: I think technically the first zero calorie sugar would have been literal lead (as in Pb) back in the ancient roman days, but I’m not really counting that.

Jumping in down here. I agree with you entirely that racemic mixes are a very different ball than mirror organisms; it’s been a known thing for a long time, and while I’m not positive, I’d be very surprised if FDA testing didn’t include different chiralities of both the original compound and metabolite.

That being said, there’s nothing to say one version of a chiral protein can’t behave like a prion. I don’t know of any evidence where we’ve seen it happen either, though. There’s also potentially the issue of partial bonding. Not every domain on every protein is chiral. If a mirror protein has some domains that bind but other functional domains that are incompatible, you could see it incorporated into complex that either 1) are now non-functional or 2) have alternate folding that behaves similar to prions.

Again though, I can’t point to any evidence of that. You can do the arrow pushing that shows how you get tetrodoxin from the stuff in your tea or coffee, it doesn’t mean it’s actually going to happen beyond the statistical realm interesting only to quantum physicists.

Just chiming in because your comments are level headed and you’ve clearly got some knowledge in the area and appreciate the discussion. Looking forward to digging into the report this weekend, I had no idea this was even something are even attempting!

I’m no hero, just doing what I can.

Yank. Can second. Unless it was well and truly off most bartenders would just laugh at you. You might get an exception if you’re in the kind of joint that’s $20 for a Sam Adam’s or something because at that point it’s not a pub it’s an adult daycare.